| http://purl.uniprot.org/citations/28236654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28236654 | http://www.w3.org/2000/01/rdf-schema#comment | "Sortilin 1 (Sort1) is a trafficking receptor that has been implicated in the regulation of plasma cholesterol in humans and mice. Here, we use metabolomics and hyperinsulinemic-euglycemic clamp approaches to obtain further understanding of the in vivo effects of Sort1 deletion on diet-induced obesity as well as on adipose lipid and glucose metabolism. Results show that Sort1 knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations. Under the basal fasting state, chow-fed Sort1 KO mice have decreased adipose glycolytic metabolites, but Sort1 deletion does not affect insulin-stimulated tissue glucose uptake during the insulin clamp. These results suggest that Sort1 loss-of-function in vivo does not affect obesity development, but differentially modulates adipose glucose metabolism under fasting and insulin-stimulated states."xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12610"xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/author | "Matye D.J."xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/pages | "1018-1028"xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/title | "Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice."xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://purl.uniprot.org/core/volume | "591"xsd:string |
| http://purl.uniprot.org/citations/28236654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28236654 |
| http://purl.uniprot.org/citations/28236654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28236654 |
| http://purl.uniprot.org/uniprot/#_Q6PHU5-mappedCitation-28236654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28236654 |
| http://purl.uniprot.org/uniprot/Q6PHU5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28236654 |