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| http://purl.uniprot.org/citations/28238659 | http://www.w3.org/2000/01/rdf-schema#comment | "At least some animal species can generate neurons from mesoderm or endoderm, but the underlying mechanisms remain unknown. We screened for C. elegans mutants in which the presumptive mesoderm-derived I4 neuron adopts a muscle-like cell fate. From this screen, we identified HLH-3, the C. elegans homolog of a mammalian proneural protein (Ascl1) used for in vitro neuronal reprogramming, as required for efficient I4 neurogenesis. We discovered that the CDK-8 Mediator kinase module acts together with a second proneural protein, HLH-2, and in parallel to HLH-3 to promote I4 neurogenesis. Genetic analysis revealed that CDK-8 most likely promotes I4 neurogenesis by inhibiting the CDK-7/CYH-1 (CDK7/cyclin H) kinase module of the transcription initiation factor TFIIH. Ectopic expression of HLH-2 and HLH-3 together promoted expression of neuronal features in non-neuronal cells. These findings reveal that the Mediator CDK8 kinase module can promote non-ectodermal neurogenesis and suggest that inhibiting CDK7/cyclin H might similarly promote neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/28238659 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2017.01.056"xsd:string |
| http://purl.uniprot.org/citations/28238659 | http://purl.uniprot.org/core/author | "Luo S."xsd:string |
| http://purl.uniprot.org/citations/28238659 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/28238659 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28238659 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/28238659 | http://purl.uniprot.org/core/pages | "661-672"xsd:string |
| http://purl.uniprot.org/citations/28238659 | http://purl.uniprot.org/core/title | "The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage."xsd:string |
| http://purl.uniprot.org/citations/28238659 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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