| http://purl.uniprot.org/citations/2823881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2823881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2823881 | http://www.w3.org/2000/01/rdf-schema#comment | "The Fur (ferric uptake regulation) protein is a negative regulator of the aerobactin operon and of several other siderophore-mediated, high-affinity iron transport systems in Escherichia coli. The purified Fur protein and a plasmid containing a lacZ fusion to the aerobactin operon were used in conjunction with an in vitro coupled transcription/translation system to demonstrate that the Fur protein requires Fe(II) or certain other divalent metals as a cofactor to negatively regulate expression of the aerobactin operon. In a second set of experiments, using a restriction site protection assay, Fur was shown to bind to and block the aerobactin promoter in a metal-dependent fashion. It is concluded that Fur acts as a classical negative repressor that, under in vivo conditions, uses ionic Fe(II) as a corepressor. Our results support the hypothesis [Williams, R.J.P. (1982) FEBS Lett. 140, 3-10] that prokaryotic cells may contain a standing pool of free or loosely bound Fe(II) that is capable of acting in a regulatory capacity."xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi00391a039"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi00391a039"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/author | "Neilands J.B."xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/author | "Neilands J.B."xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/author | "Bagg A."xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/author | "Bagg A."xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/pages | "5471-5477"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/pages | "5471-5477"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/title | "Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli."xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/title | "Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli."xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/2823881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2823881 |
| http://purl.uniprot.org/citations/2823881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2823881 |
| http://purl.uniprot.org/citations/2823881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2823881 |
| http://purl.uniprot.org/citations/2823881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2823881 |
| http://purl.uniprot.org/uniprot/A0A8B6X149 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/2823881 |
| http://purl.uniprot.org/uniprot/P0A9A9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/2823881 |