| http://purl.uniprot.org/citations/28240259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28240259 | http://www.w3.org/2000/01/rdf-schema#comment | "Cardiovascular complications determine morbidity/mortality in chronic kidney disease (CKD). We hypothesized that progressive CKD drives the release of cathepsin-S (Cat-S), a cysteine protease that promotes endothelial dysfunction and cardiovascular complications. Therefore, Cat-S, soluble tumor-necrosis-factor receptor (sTNFR) 1/2 and glomerular filtration rate (GFR) were measured in a CKD mouse model, a German CKD-cohort (MCKD, n = 421) and two Swedish community-based cohorts (ULSAM, n = 764 and PIVUS, n = 804). Association between Cat-S and sTNFR1/2/GFR was assessed using multivariable linear regression. In the mouse model, Cat-S and sTNFR1/2 concentrations were increased following the progressive decline of GFR, showing a strong correlation between Cat-S and GFR (r = -0.746, p < 0.001) and Cat-S and sTNFR1/sTNFR2 (r = 0.837/0.916, p < 0.001, respectively). In the human cohorts, an increase of one standard deviation of estimated GFR was associated with a decrease of 1.008 ng/ml (95%-confidence interval (95%-CI) -1.576-(-0.439), p < 0.001) in Cat-S levels in MCKD; in ULSAM and PIVUS, results were similar. In all three cohorts, Cat-S and sTNFR1/sTNFR2 levels were associated in multivariable linear regression (p < 0.001). In conclusion, as GFR declines Cat-S and markers of inflammation-related endothelial dysfunction increase. The present data indicating that Cat-S activity increases with CKD progression suggest that Cat-S might be a therapeutic target to prevent cardiovascular complications in CKD."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep43538"xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Larsson A."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Heemann U."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Renders L."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Arnlov J."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Tato M."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Anders H.J."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Lind L."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Steubl D."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Kumar S.V."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Riserus U."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Mulay S.R."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/author | "Carlsson A.C."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/pages | "43538"xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/title | "Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans."xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28240259 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28240259 |
| http://purl.uniprot.org/citations/28240259 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28240259 |
| http://purl.uniprot.org/uniprot/#_A0A7P0TB77-mappedCitation-28240259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28240259 |
| http://purl.uniprot.org/uniprot/#_F6WR04-mappedCitation-28240259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28240259 |
| http://purl.uniprot.org/uniprot/#_P25774-mappedCitation-28240259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28240259 |