| http://purl.uniprot.org/citations/28241483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28241483 | http://www.w3.org/2000/01/rdf-schema#comment | "Hyperglycemia results in accumulation of the reactive dicarbonyl methylglyoxal (MG). Methylglyoxal is detoxified by the glyoxalase system (glyoxalase 1 and 2). The influence of glyoxalase 1 knockdown on expression of collagens 1, 3, 4, and 5 in L6 myoblasts under hyperglycemic conditions was investigated. Increased biosynthesis of collagens 1, 3, 4, and 5 was detected at mRNA-level following knockdown of glyoxalase 1 (GLO1). At the protein level a significant elevation of the concentration of collagen 1 and 4 was shown, whereas no increase of collagen 5 and a non-significant increase in collagen 3 were detectable. These results could partially explain MG-induced changes in the extracellular matrix (ECM) which account for increased fibrosis and impaired function in myocytes. The mechanisms by which reactive glucose metabolites influence ECM composition deserve further investigation."xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms18030480"xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/author | "Goldstein B."xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/author | "Tschoepe D."xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/author | "Thornalley P.J."xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/author | "Stratmann B."xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/author | "Rabbani N."xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/pages | "E480"xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/title | "Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts."xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/28241483 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28241483 |
| http://purl.uniprot.org/citations/28241483 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28241483 |
| http://purl.uniprot.org/uniprot/#_A6JJX3-mappedCitation-28241483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28241483 |
| http://purl.uniprot.org/uniprot/#_Q6P7Q4-mappedCitation-28241483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28241483 |
| http://purl.uniprot.org/uniprot/Q6P7Q4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28241483 |
| http://purl.uniprot.org/uniprot/A6JJX3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28241483 |