| http://purl.uniprot.org/citations/28246125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28246125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28246125 | http://www.w3.org/2000/01/rdf-schema#comment | "Zinc metallopeptidase STE24 (ZMPSTE24) is a transmembrane metalloprotease whose catalytic activity is critical for processing lamin A on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum. We now report ZMPSTE24 is a virus-specific effector that restricts enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia, but not murine leukemia or adenovirus. ZMPSTE24-mediated antiviral action is independent of protease activity. Coimmunoprecipitation studies indicate ZMPSTE24 can complex with proteins of the interferon-induced transmembrane protein (IFITM) family. IFITM proteins impede viral entry, and ZMPSTE24 expression is necessary for IFITM antiviral activity. In vivo studies demonstrate ZMPSTE24-deficient mice display higher viral burdens, enhanced cytokine production, and increased mortality after influenza infection. Collectively, these findings identify ZMPSTE24 as an intrinsic broad-spectrum antiviral protein and provide insights into antiviral defense mechanisms."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20161270"xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20161270"xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Fu B."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Fu B."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Dorf M.E."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/author | "Dorf M.E."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/pages | "919-929"xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/pages | "919-929"xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/title | "ZMPSTE24 defends against influenza and other pathogenic viruses."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/title | "ZMPSTE24 defends against influenza and other pathogenic viruses."xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/28246125 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28246125 |
| http://purl.uniprot.org/citations/28246125 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28246125 |