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http://purl.uniprot.org/citations/28247576http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28247576http://www.w3.org/2000/01/rdf-schema#comment"

Background

Type 1 diabetes (T1D) and celiac disease (CeD) are 2 distinct diseases, but there is an increased risk of developing CeD for T1D patients. Both diseases are associated with HLA-class II alleles, such as DQB1 *02:01 and DQB1 *03:02; however, their risk contribution vary between the diseases.

Materials and methods

We genotyped HLA-DRB1 and - DQB1 in 215 patients with coexisting T1D and CeD identified from a T1D cohort, and compared them to patients with T1D (N = 487) and CeD (N = 327), as well as healthy controls (N = 368).

Results

The patients with coexisting T1D and CeD had an intermediate carrier frequency (72.8%) of the DRB1 *03:01-DQB1 *02:01-DQA1 *05:01 haplotype compared to T1D (64.1%) and CeD (88.7%) patients. The DRB1 *03:01- DQB1 *02:01- DQA1 *05:01/ DRB1 *04- DQB1 *03:02-DQA1 *03 haplotype combination, encoding DQ2.5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%).

Conclusion

Overall, the patients with coexisting T1D and CeD had an HLA profile more similar to T1D patients than CeD patients."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.org/dc/terms/identifier"doi:10.1111/tan.12986"xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Viken M.K."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Sollid L.M."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Amundsen S.S."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Joner G."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Lie B.A."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Dahl-Jorgensen K."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Flam S.T."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Drivvoll A.K."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/author"Skrivarhaug T."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/name"HLA"xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/pages"278-284"xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/title"HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease."xsd:string
http://purl.uniprot.org/citations/28247576http://purl.uniprot.org/core/volume"89"xsd:string
http://purl.uniprot.org/citations/28247576http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28247576
http://purl.uniprot.org/citations/28247576http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28247576
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http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-28247576http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28247576
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http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-28247576http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28247576
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