http://purl.uniprot.org/citations/28249647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/28249647 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo determine clinicopathologic factors on survival in patients with head and neck synovial sarcoma.Patients and methodsWe retrospectively identified patients with molecularly confirmed synovial sarcomas of the head and neck (SS-HN), either by the presence of SS18-SSX fusion transcript by RT-PCR or SS18 gene rearrangement by FISH, who were managed at our institution over a 20-year period (1996-2015). Kaplan-Meier survival analysis and log-rank test were performed to evaluate variables related to disease specific survival (DSS). Fisher exact test was performed to evaluate variables related to local recurrence.ResultsThirty-four patients (20 males and 14 females, mean of 31years) with SS18-SSX fusion-positive SS-HN were identified. The parapharyngeal region of the neck was the most common site. The mean tumor size was 4.8cm (0.8-10cm). Two-thirds (n=23) of cases had a monophasic histology. The 2, 5 and 10-year DSS rates were 97%, 79% and 68%. The 5-year DSS rates for the adult/pediatric cohort were 74%/88%. Recurrence showed significant effect on DSS (p=0.021). There was no significant effect on DSS with age, therapy modality, tumor site, surgical margin, tumor size (⩽5cm vs. >5cm) and histopathologic subtype. Tumor site (i.e. skull base/paranasal sinus region) was associated with local recurrence (p=0.003).ConclusionIn our cohort DSS rate was associated with recurrence. Tumors located in the skull base/paranasal sinus region were associated with a higher rate of local recurrence. Thus appropriate selection of high risk patients who can benefit from multimodality therapies might improve survival."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.oraloncology.2016.12.021"xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/author | "Antonescu C.R."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/author | "Estilo C.L."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/author | "Huryn J.M."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/author | "Owosho A.A."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/author | "Rosen E.B."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/author | "Yom S.K."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/name | "Oral Oncol"xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/pages | "46-51"xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/title | "A clinicopathologic study on SS18 fusion positive head and neck synovial sarcomas."xsd:string |
http://purl.uniprot.org/citations/28249647 | http://purl.uniprot.org/core/volume | "66"xsd:string |
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