| http://purl.uniprot.org/citations/2825027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2825027 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus-1 (HIV-1) gene expression is controlled by cellular transcription factors and by virally encoded trans-activation proteins of the HIV-1 tat and art/trs genes, which are essential for viral replication. Tat trans-activates HIV-1 gene expression by interacting with the trans-acting response element (TAR) located within the HIV-1 long terminal repeat (LTR) (ref. 2). In transient expression assays, tat mediates its effects largely by increasing the steady-state levels of messenger RNA species that contain the TAR sequence at or near their 5' ends, suggesting a function for tat either in transcription or in subsequent RNA processing. The tat gene could also facilitate translation of mRNA containing the TAR sequence. To determine the mechanism of trans-activation by tat, we analysed the structure and rate of synthesis of RNA species directed by the HIV-1 LTR in transient expression assays both in the presence and absence of tat. Although the rate of HIV-1 transcription initiation was not affected by tat, transcriptional elongation beyond position +59 was seen only in the presence of tat. Thus, tat trans-activates HIV-1 transcription by relieving a specific block to transcriptional elongation within the TAR sequence."xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.org/dc/terms/identifier | "doi:10.1038/330489a0"xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/author | "Luciw P.A."xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/author | "Calman A.F."xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/author | "Kao S.Y."xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/pages | "489-493"xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/title | "Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product."xsd:string |
| http://purl.uniprot.org/citations/2825027 | http://purl.uniprot.org/core/volume | "330"xsd:string |
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