| http://purl.uniprot.org/citations/28256087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28256087 | http://www.w3.org/2000/01/rdf-schema#comment | "Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell lymphoma subtype, and the Epstein-Barr virus (EBV)-positive subtype of DLBCL is known to show a more aggressive clinical behavior than the EBV-negative one. BTB and CNC homology 2 (BACH2) has been highlighted as a tumor suppressor in hematopoietic malignancies; however, the role of BACH2 in EBV-positive DLBCL is unclear. In the present study, BACH2 expression and its significance were studied in 23 EBV-positive and 43 EBV-negative patient samples. Immunohistochemistry revealed BACH2 downregulation in EBV-positive cases (P < 0.0001), although biallelic deletion of BACH2 was not detected by FISH. Next, we analyzed the contribution of BACH2 negativity to aggressiveness in EBV-positive B-cell lymphomas using FL-18 (EBV-negative) and FL-18-EB cells (FL-18 sister cell line, EBV-positive). In BACH2-transfected FL-18-EB cells, downregulation of phosphorylated transforming growth factor-β-activated kinase 1 (pTAK1) and suppression in p65 nuclear fractions were observed by Western blot analysis contrary to non-transfected FL-18-EB cells. In patient samples, pTAK1 expression and significant nuclear p65, p50, and p52 localization were detected immunohistochemically in BACH2-negative DLBCL (P < 0.0001, P = 0.006, and P = 0.001, respectively), suggesting that BACH2 downregulation contributes to constitutive activation of the nuclear factor-κB pathway through TAK1 phosphorylation in BACH2-negative DLBCL (most EBV-positive cases). Although further molecular and pathological studies are warranted to clarify the detailed mechanisms, downregulation of BACH2 may contribute to constitutive activation of the nuclear factor-κB pathway through TAK1 activation."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.13213"xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Igarashi K."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Ito E."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Taniguchi K."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Sakurai H."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Takata K."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Yoshino T."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Tabata T."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Ohnishi N."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Omote S."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Miyata-Takata T."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Noujima-Harada M."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/author | "Nagakita K."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/pages | "1071-1079"xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/title | "Frequent downregulation of BTB and CNC homology 2 expression in Epstein-Barr virus-positive diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/28256087 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28256087 |
| http://purl.uniprot.org/citations/28256087 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28256087 |
| http://purl.uniprot.org/uniprot/#_S6CM55-mappedCitation-28256087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28256087 |
| http://purl.uniprot.org/uniprot/#_S6CMK8-mappedCitation-28256087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28256087 |