| http://purl.uniprot.org/citations/28256515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28256515 | http://www.w3.org/2000/01/rdf-schema#comment | "Two distinct monocyte (Mo)/macrophage (Mp) subsets (Ly6Clow and Ly6Chigh) orchestrate cardiac recovery process following myocardial infarction (MI). Prostaglandin (PG) E2 is involved in the Mo/Mp-mediated inflammatory response, however, the role of its receptors in Mos/Mps in cardiac healing remains to be determined. Here we show that pharmacological inhibition or gene ablation of the Ep3 receptor in mice suppresses accumulation of Ly6Clow Mos/Mps in infarcted hearts. Ep3 deletion in Mos/Mps markedly attenuates healing after MI by reducing neovascularization in peri-infarct zones. Ep3 deficiency diminishes CX3C chemokine receptor 1 (CX3CR1) expression and vascular endothelial growth factor (VEGF) secretion in Mos/Mps by suppressing TGFβ1 signalling and subsequently inhibits Ly6Clow Mos/Mps migration and angiogenesis. Targeted overexpression of Ep3 receptors in Mos/Mps improves wound healing by enhancing angiogenesis. Thus, the PGE2/Ep3 axis promotes cardiac healing after MI by activating reparative Ly6Clow Mos/Mps, indicating that Ep3 receptor activation may be a promising therapeutic target for acute MI."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14656"xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Lazarus M."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Zuo S."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Wan Q."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Tao B."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/author | "Yu Y.'"xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/pages | "14656"xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/title | "Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction."xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28256515 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28256515 |
| http://purl.uniprot.org/citations/28256515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28256515 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-28256515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28256515 |