| http://purl.uniprot.org/citations/28257000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28257000 | http://www.w3.org/2000/01/rdf-schema#comment | "Unfavorable redox conditions in the endoplasmic reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions. While systems to manage reductive stress are well-established, how cells cope with an overly oxidizing ER remains largely undefined. In previous work (Wang et al., 2014), we demonstrated that the chaperone BiP is a sensor of overly oxidizing ER conditions. We showed that modification of a conserved BiP cysteine during stress beneficially alters BiP chaperone activity to cope with suboptimal folding conditions. How this cysteine is reduced to reestablish 'normal' BiP activity post-oxidative stress has remained unknown. Here we demonstrate that BiP's nucleotide exchange factor - Sil1 - can reverse BiP cysteine oxidation. This previously unexpected reductant capacity for yeast Sil1 has potential implications for the human ataxia Marinesco-Sjögren syndrome, where it is interesting to speculate that a disruption in ER redox-signaling (due to genetic defects in SIL1) may influence disease pathology."xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.24141"xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/author | "Sevier C.S."xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/author | "Pareja K.A."xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/author | "Siegenthaler K.D."xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/pages | "e24141"xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/title | "An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP."xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28257000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28257000 |
| http://purl.uniprot.org/citations/28257000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28257000 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BUM1-mappedCitation-28257000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28257000 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BYJ9-mappedCitation-28257000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28257000 |
| http://purl.uniprot.org/uniprot/#_P16474-mappedCitation-28257000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28257000 |
| http://purl.uniprot.org/uniprot/#_Q08199-mappedCitation-28257000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28257000 |
| http://purl.uniprot.org/uniprot/A0A8H4BUM1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28257000 |
| http://purl.uniprot.org/uniprot/Q08199 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28257000 |
| http://purl.uniprot.org/uniprot/A0A8H4BYJ9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28257000 |
| http://purl.uniprot.org/uniprot/P16474 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28257000 |