| http://purl.uniprot.org/citations/28257056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28257056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28257056 | http://www.w3.org/2000/01/rdf-schema#comment | "Toxin/antitoxin (TA) systems are widespread in prokaryotic chromosomes and in mobile genetic elements including plasmids and prophages. The first characterized Type IV TA system CbtA/CbeA was found in cryptic prophage CP4-44 in Escherichia coli K-12. Two homologous TA loci of CbtA/CbeA also reside in cryptic prophages of E. coli K-12, YkfI/YafW in CP4-6 and YpjF/YfjZ in CP4-57. In this study, we demonstrated that YkfI and YpjF inhibited cell growth and led to the formation of "lemon-shaped" cells. Prolonged overproduction of YkfI led to the formation of "gourd-shaped" cells and immediate cell lysis. YafW and YfjZ can neutralize the toxicity of YkfI or YpjF. Furthermore, we found that YkfI and YpjF interacted with cell division protein FtsZ in E. coli, but ectopic expression in Pseudomonas and Shewanella did not cause the formation of "lemon-shaped" cells. Moreover, deletion of all of the three toxin genes together decreased resistance to oxidative stress and deletion of the antitoxin genes increased early biofilm formation. Collectively, these results demonstrated that the homologous Type IV TA systems in E. coli may target cell division protein FtsZ in E. coli and may have different physiological functions in E. coli."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.org/dc/terms/identifier | "doi:10.3390/toxins9030077"xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.org/dc/terms/identifier | "doi:10.3390/toxins9030077"xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Wen Z."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/author | "Wen Z."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/name | "Toxins"xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/name | "Toxins"xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/title | "Interaction of type IV toxin/antitoxin systems in cryptic prophages of Escherichia coli K-12."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/title | "Interaction of type IV toxin/antitoxin systems in cryptic prophages of Escherichia coli K-12."xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/28257056 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28257056 |
| http://purl.uniprot.org/citations/28257056 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28257056 |