| http://purl.uniprot.org/citations/28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28264927 | http://www.w3.org/2000/01/rdf-schema#comment | "Surface expression of chemokine receptor CXCR4 is downregulated by missing-in-metastasis protein (MIM; also known as MTSS1), a member of the inverse BAR (I-BAR)-domain protein family that recognizes and generates membranes with negative curvature. Yet, the mechanism for the regulation is unknown. Here, we show that MIM forms a complex with CXCR4 by binding to E3 ubiquitin ligase AIP4 (also known as ITCH) in response to stromal cell-derived factor 1 (SDF-1; also known as CXCL12). Overexpression of MIM promoted CXCR4 ubiquitylation, inhibited cellular response to SDF-1, caused accumulation and aggregation of multivesicular bodies (MVBs) in the cytoplasm, and promoted CXCR4 sorting into MVBs in a manner depending on binding to AIP4. In response to SDF-1, MIM also bound transiently to the small GTPase Rab5 at 5 min and to Rab7 at 30 min. Binding to Rab7 requires an N-terminal coiled-coil motif, deletion of which abolished MIM-mediated MVB formation and CXCR4 internalization. Our results unveil a previously unknown property of MIM that establishes the linkage of protein ubiquitylation with Rab-guided trafficking of CXCR4 in endocytic vesicles."xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.198937"xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/author | "Ji M."xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/author | "Gu N."xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/author | "Baxter S.S."xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/pages | "1475-1485"xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/title | "Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases."xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/28264927 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28264927 |
| http://purl.uniprot.org/citations/28264927 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28264927 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVG9-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVR6-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0N8-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
| http://purl.uniprot.org/uniprot/#_P70658-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
| http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
| http://purl.uniprot.org/uniprot/#_A0A0U3GXA9-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3WLL1-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPM9-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |
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| http://purl.uniprot.org/uniprot/#_A0A2I3BQ92-mappedCitation-28264927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28264927 |