| http://purl.uniprot.org/citations/28273452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28273452 | http://www.w3.org/2000/01/rdf-schema#comment | "While the multiple endocrine neoplasia type 1 (MEN1) gene functions as a tumor suppressor in a variety of cancer types, we explored its oncogenic role in breast tumorigenesis. The MEN1 gene product menin is involved in H3K4 trimethylation and co-activates transcription. We integrated ChIP-seq and RNA-seq data to identify menin target genes. Our analysis revealed that menin-dependent target gene promoters display looping to distal enhancers that are bound by menin, FOXA1 and GATA3. In this fashion, MEN1 co-regulates a proliferative breast cancer-specific gene expression program in ER+ cells. In primary mammary cells, MEN1 exerts an anti-proliferative function by regulating a distinct expression signature. Our findings clarify the cell-type-specific functions of MEN1 and inform the development of menin-directed treatments for breast cancer."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.02.025"xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Brown M."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Gu L."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Lin C.Y."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Cook J."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Chi D."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Lim E."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Reyes J."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "de Laat W."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Vos E.S.M."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Rao P.K."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Groner A.C."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Long H.W."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Font-Tello A."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/author | "Dreijerink K.M.A."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/pages | "2359-2372"xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/title | "Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer."xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/28273452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28273452 |
| http://purl.uniprot.org/citations/28273452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28273452 |
| http://purl.uniprot.org/uniprot/#_C9DZM4-mappedCitation-28273452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28273452 |