| http://purl.uniprot.org/citations/2827463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2827463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2827463 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytochrome P-450 monooxygenase system possesses catalytic activity toward many exogenous compounds (e.g., drugs, insecticides, and polycyclic aromatic hydrocarbons) and endogenous compounds (e.g., steroids, fatty acids, and prostaglandins). Multiple forms of cytochrome P-450 with different substrate specificities have been isolated. In the present paper we report the isolation and sequence of a cDNA clone for the human hepatic cytochrome P-450 responsible for mephenytoin (an anticonvulsant) oxidation. The mephenytoin cytochrome P-450 is analogous to the rat cytochrome P-450 form termed PB-1 (family P450C2C). We also report that human PB-1 is encoded by one of a small family of related genes all of which map to human chromosome 10q24.1-10q24.3. The endogenous role of this enzyme appears to be in steroid oxidations. This cytochrome P-450 family does not correspond to any of the hepatic cytochrome P-450 gene families previously mapped in humans."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Hastie N.D."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Hastie N.D."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Buckland R."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Buckland R."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "van Heyningen V."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "van Heyningen V."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Fletcher J.M."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Fletcher J.M."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Wolf C.R."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Wolf C.R."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Sweeney J."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Sweeney J."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Spurr N.K."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Spurr N.K."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Adesnik M."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Adesnik M."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Friedberg T."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Friedberg T."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Gosden J.R."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Gosden J.R."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Meehan R.R."xsd:string |
| http://purl.uniprot.org/citations/2827463 | http://purl.uniprot.org/core/author | "Meehan R.R."xsd:string |