| http://purl.uniprot.org/citations/28276429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28276429 | http://www.w3.org/2000/01/rdf-schema#comment | "Of the many serotonin receptors, the type 3 receptors (5-HT3R) are the only ionotropic ones, playing a key role in fast synaptic transmission and cognitive and emotional brain function through controlled neuronal excitation. To better understand the various functions of 5-HT3Rs, it is very important to know their expression pattern in the central nervous system (CNS). To date, many distributional studies have shown localized 5-HT3R expression in the brain and spinal cord. However, an accurate pattern of 5-HT3R expression in the CNS remains to be elucidated. To investigate the distribution of 5-HT3R in the mouse brain in detail, we performed immunofluorescent staining using 5-HT3AR-GFP transgenic mice. We found strong 5-HT3AR expression in the olfactory bulb, cerebral cortex, hippocampus, and amygdala; and partial expression in the pons, medulla, and spinal cord. Meanwhile, the thalamus, hypothalamus, and midbrain exhibited a few 5-HT3AR-expressing cells, and no expression was detected in the cerebellum. Further, double-immunostaining using neural markers confirmed that 5-HT3AR is expressed in GABAergic interneurons containing somatostatin or calretinin. In the present study, we built a 5-HT3AR expression map in the mouse brain. Our findings make significant contributions in elucidating the novel functions of 5-HT3R in the CNS."xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep42884"xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/author | "Kondo M."xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/author | "Koyama Y."xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/author | "Shimada S."xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/pages | "42884"xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/title | "Building a 5-HT3A Receptor Expression Map in the Mouse Brain."xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28276429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28276429 |
| http://purl.uniprot.org/citations/28276429 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28276429 |
| http://purl.uniprot.org/uniprot/#_B7ZMU3-mappedCitation-28276429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/#_P23979-mappedCitation-28276429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/#_Q8K1F4-mappedCitation-28276429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/#_Q6J1J7-mappedCitation-28276429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/#_Q6LCB3-mappedCitation-28276429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/P23979 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/Q8K1F4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/Q6LCB3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/Q6J1J7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28276429 |
| http://purl.uniprot.org/uniprot/B7ZMU3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28276429 |