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http://purl.uniprot.org/citations/28278213http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28278213http://www.w3.org/2000/01/rdf-schema#comment"

Background

Matrix metalloproteinase 8 (MMP-8) is the most potent type-I collagen protease. Such collagen mainly constitutes the transient fibrosis in takotsubo cardiomyopathy (TTC) endomyocardial biopsies. High MMP-8 and tissue-inhibitor of matrix metalloproteinase-1 (TIMP-1) levels are implicated in acute coronary syndrome (ACS). We compared MMP-8 and TIMP-1 levels in consecutive TTC and ACS patients, and their association to TTC severity.

Methods and results

In 45 acute serum samples of TTC, 2072 ACS and 1000 controls, TIMP-1 differed between ACS 146.7ng/mL (115.0-186.3) (median (interquartile range)), TTC 115.7 (94.3-137.7) and controls 80.9 (73.2-90.4), (p<0.0001). MMP-8 levels were similar between ACS and TTC. In receiver-operating characteristics analysis, TIMP-1 differentiated TTC from ACS with an area under the curve (AUC) of 0.679 (p<0.0001) surpassing troponin T (TnT) at 0.522 (p = 0.66). Compared to other differing factors (age, sex, smoking), TIMP-1 improved diagnostic specificity and sensitivity from AUC of 0.821 to 0.844 (p = 0.007). The MMP8/TIMP-1 molar ratio differentiated normal ejection fraction (EF) at 0.27 (0.13-0.51) from decreased EF<50% at 0.08 (0.05-0.20), (p = 0.04) in TTC, but not in ACS.

Conclusions

Even with other differing factors considered, TIMP-1 differentiated TTC from ACS better than TnT. In TTC, the low MMP-8/TIMP-1 molar ratio may reflect decreased proteolysis and increased transient fibrosis, perhaps in part explaining the left-ventricle impairment."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0173371"xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Salomaa V."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Perola M."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Sinisalo J."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Jousilahti P."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Sorsa T."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Pussinen P.J."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Tervahartiala T."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Nieminen M.T."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Parkkonen O."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/author"Vesterinen P."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/pages"e0173371"xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/title"Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome."xsd:string
http://purl.uniprot.org/citations/28278213http://purl.uniprot.org/core/volume"12"xsd:string
http://purl.uniprot.org/citations/28278213http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28278213
http://purl.uniprot.org/citations/28278213http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28278213
http://purl.uniprot.org/uniprot/#_B3KQF4-mappedCitation-28278213http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28278213
http://purl.uniprot.org/uniprot/#_A8K9E4-mappedCitation-28278213http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28278213
http://purl.uniprot.org/uniprot/#_B4E0T0-mappedCitation-28278213http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28278213
http://purl.uniprot.org/uniprot/#_B4E0I2-mappedCitation-28278213http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28278213
http://purl.uniprot.org/uniprot/#_B4DJK3-mappedCitation-28278213http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28278213
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