| http://purl.uniprot.org/citations/28285904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28285904 | http://www.w3.org/2000/01/rdf-schema#comment | "Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell (ISC) populations have been described, the identity and features of such a population remain controversial. Here we report unanticipated heterogeneity within the Lgr5+ ISC pool. We found that expression of the RNA-binding protein Mex3a labels a slowly cycling subpopulation of Lgr5+ ISCs that contribute to all intestinal lineages with distinct kinetics. Single-cell transcriptome profiling revealed that Lgr5+ cells adopt two discrete states, one of which is defined by a Mex3a expression program and relatively low levels of proliferation genes. During homeostasis, Mex3a+ cells continually shift into the rapidly dividing, self-renewing ISC pool. Chemotherapy and radiation preferentially target rapidly dividing Lgr5+ cells but spare the Mex3a-high/Lgr5+ population, helping to promote regeneration of the intestinal epithelium following toxic insults. Thus, Mex3a defines a reserve-like ISC population within the Lgr5+ compartment."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2017.02.007"xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Gut M."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Yilmaz O.H."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Gut I."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Winton D.J."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Batlle E."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Mendez-Lago M."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Heyn H."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Rodriguez-Esteban G."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Guillaumet-Adkins A."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Mana M."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Montagni E."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Sevillano M."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Barriga F.M."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Hernando-Momblona X."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Attolini C.S."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/author | "Buczacki S.J.A."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/pages | "801-816.e7"xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/title | "Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells."xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/28285904 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28285904 |