| http://purl.uniprot.org/citations/28286232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28286232 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroid receptor coactivator-1 (SRC-1), a well-studied coactivator of estrogen receptor (ER), is known to play an important and functional role in the development and maintenance of bone tissue. Previous reports suggest SRC-1 maintains bone mineral density primarily through its interaction with ER. Here we demonstrate that SRC-1 can also affect bone development independent of estrogen signaling as ovariectomized SRC-1 knockout (SRC-1 KO) mouse had decreased bone mineral density. To identify estrogen-independent SRC-1 target genes in osteoblastogenesis, we undertook an integrated analysis utilizing ChIP-Seq and mRNA microarray in transformed osteoblast-like U2OS-ERα cells. We identified critical osteoblast differentiation genes regulated by SRC-1, but not by estrogen including alkaline phosphatase and osteocalcin. Ex vivo primary culture of osteoblasts from SRC-1 wild-type and KO mice confirmed the role of SRC-1 in osteoblastogenesis, associated with altered ALPL levels. Together, these data indicate that SRC-1 can impact osteoblast function in an ER-independent manner."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2017.03.005"xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Liao L."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Rae J.M."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Oesterreich S."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Hartmaier R.J."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Watters R.J."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Gillihan R.M."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/author | "Osmanbeyoglu H.U."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/pages | "21-27"xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/title | "Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen."xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://purl.uniprot.org/core/volume | "448"xsd:string |
| http://purl.uniprot.org/citations/28286232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28286232 |
| http://purl.uniprot.org/citations/28286232 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28286232 |
| http://purl.uniprot.org/uniprot/#_A8K1V4-mappedCitation-28286232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28286232 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7S6-mappedCitation-28286232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28286232 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P881-mappedCitation-28286232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28286232 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6K7-mappedCitation-28286232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28286232 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7C1-mappedCitation-28286232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28286232 |