| http://purl.uniprot.org/citations/28287099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28287099 | http://www.w3.org/2000/01/rdf-schema#comment | "Correct outer protein shell assembly is a prerequisite for virion infectivity in many multi-shelled dsRNA viruses. In the prototypic dsRNA bacteriophage φ6, the assembly reaction is promoted by calcium ions but its biomechanics remain poorly understood. Here, we describe the near-atomic resolution structure of the φ6 double-shelled particle. The outer T=13 shell protein P8 consists of two alpha-helical domains joined by a linker, which allows the trimer to adopt either a closed or an open conformation. The trimers in an open conformation swap domains with each other. Our observations allow us to propose a mechanistic model for calcium concentration regulated outer shell assembly. Furthermore, the structure provides a prime exemplar of bona fide domain-swapping. This leads us to extend the theory of domain-swapping from the level of monomeric subunits and multimers to closed spherical shells, and to hypothesize a mechanism by which closed protein shells may arise in evolution."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14814"xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "Huiskonen J.T."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "Kotecha A."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "Poranen M.M."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "El Omari K."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/author | "Ilca S.L."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/pages | "14814"xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/title | "Double-stranded RNA virus outer shell assembly by bona fide domain-swapping."xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28287099 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28287099 |
| http://purl.uniprot.org/citations/28287099 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28287099 |
| http://purl.uniprot.org/uniprot/#_P11125-mappedCitation-28287099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28287099 |
| http://purl.uniprot.org/uniprot/#_P11126-mappedCitation-28287099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28287099 |
| http://purl.uniprot.org/uniprot/#_P07579-mappedCitation-28287099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28287099 |
| http://purl.uniprot.org/uniprot/P11125 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28287099 |
| http://purl.uniprot.org/uniprot/P11126 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28287099 |
| http://purl.uniprot.org/uniprot/P07579 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28287099 |