| http://purl.uniprot.org/citations/28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28292892 | http://www.w3.org/2000/01/rdf-schema#comment | "The E3 ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) has been known to mediate key signaling factors for degradation via the ubiquitin/26S proteasome pathway in both plants and animals. Here, we report a noncanonical function of Arabidopsis COP1, the central repressor of photomorphogenesis, in the form of a COP1/ SUPPRESSOR of phyA-105 (SPA) complex. We show that the COP1/SPA complex associates with and stabilizes PHYTOCHROME INTERACTING FACTOR 3 (PIF3) to repress photomorphogenesis in the dark. We identify the GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 (BIN2) as a kinase of PIF3, which induces PIF3 degradation via 26S proteasome during skotomorphogenesis. Mutations on two typical BIN2 phosphorylation motifs of PIF3 lead to a strong stabilization of the protein in the dark. We further show that the COP1/SPA complex promotes PIF3 stability by repressing BIN2 activity. Intriguingly, without affecting BIN2 expression, the COP1/SPA complex modulates BIN2 activity through interfering with BIN2-PIF3 interaction, thereby inhibiting BIN2-mediated PIF3 phosphorylation and degradation. Taken together, our results suggest another paradigm for COP1/SPA complex action in the precise control of skotomorphogenesis."xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1700850114"xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/author | "Deng X.W."xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/author | "Zhu D."xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/author | "Ling J.J."xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/pages | "3539-3544"xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/title | "Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness."xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28292892 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28292892 |
| http://purl.uniprot.org/citations/28292892 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28292892 |
| http://purl.uniprot.org/uniprot/#_A0A178VSM9-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_A0A178VXE2-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_A0A1P8B2S1-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_A0A5S9TG51-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_A0A5S9XTS4-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_F4JRM5-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_Q39011-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_O80536-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_P43254-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/#_Q9SYX2-mappedCitation-28292892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28292892 |
| http://purl.uniprot.org/uniprot/A0A5S9XTS4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28292892 |