| http://purl.uniprot.org/citations/28292928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28292928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28292928 | http://www.w3.org/2000/01/rdf-schema#comment | "Elongin A performs dual functions as the transcriptionally active subunit of RNA polymerase II (Pol II) elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that ubiquitylates Pol II in response to DNA damage. Assembly of the Elongin A ubiquitin ligase and its recruitment to sites of DNA damage is a tightly regulated process induced by DNA-damaging agents and α-amanitin, a drug that induces Pol II stalling. In this study, we demonstrate (i) that Elongin A and the ubiquitin ligase subunit CUL5 associate in cells with the Cockayne syndrome B (CSB) protein and (ii) that this interaction is also induced by DNA-damaging agents and α-amanitin. In addition, we present evidence that the CSB protein promotes stable recruitment of the Elongin A ubiquitin ligase to sites of DNA damage. Our findings are consistent with the model that the Elongin A ubiquitin ligase and the CSB protein function together in a common pathway in response to Pol II stalling and DNA damage."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c117.777946"xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c117.777946"xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Yasukawa T."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Yasukawa T."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Slaughter B.D."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Slaughter B.D."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Unruh J.R."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Unruh J.R."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Svejstrup J.Q."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Svejstrup J.Q."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Boeing S."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Boeing S."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Aso T."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Aso T."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Weems J.C."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Weems J.C."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Hall S.M."xsd:string |
| http://purl.uniprot.org/citations/28292928 | http://purl.uniprot.org/core/author | "Hall S.M."xsd:string |