| http://purl.uniprot.org/citations/28294974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28294974 | http://www.w3.org/2000/01/rdf-schema#comment | "Several recent studies have indicated that miR-30a plays critical roles in various biological processes and diseases. However, the mechanism of miR-30a participation in idiopathic pulmonary fibrosis (IPF) regulation is ambiguous. Our previous study demonstrated that miR-30a may function as a novel therapeutic target for lung fibrosis by blocking mitochondrial fission, which is dependent on dynamin-related protein1 (Drp-1). However, the regulatory mechanism between miR-30a and Drp-1 is yet to be investigated. Additionally, whether miR-30a can act as a potential therapeutic has not been verified in vivo. In this study, the miR-30a expression in IPF patients was evaluated. Computational analysis and a dual-luciferase reporter assay system were used to identify the target gene of miR-30a, and cell transfection was utilized to confirm this relationship. Ten-eleven translocation 1 (TET1) was validated as a direct target of miR-30a, and miR-30a mimic and inhibitor transfection significantly reduced and increased the TET1 protein expression, respectively. Further experimentation verified that the TET1 siRNA interference could inhibit Drp-1 promoter hydroxymethylation. Finally, miR-30a agomir was designed and applied to identify and validate the therapeutic effect of miR-30a in vivo. Our study demonstrated that miR-30a could inhibit TET1 expression through base pairing with complementary sites in the 3'untranslated region to regulate Drp-1 promoter hydroxymethylation. Furthermore, miR-30a could act as a potential therapeutic target for IPF."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms18030633"xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Zhang J.'"xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Cao G."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Lv C."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/author | "Xv P."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/pages | "E633"xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/title | "miR-30a as Potential Therapeutics by Targeting TET1 through Regulation of Drp-1 Promoter Hydroxymethylation in Idiopathic Pulmonary Fibrosis."xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/28294974 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28294974 |
| http://purl.uniprot.org/citations/28294974 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28294974 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TQT5-mappedCitation-28294974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28294974 |
| http://purl.uniprot.org/uniprot/#_B4DDQ3-mappedCitation-28294974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28294974 |
| http://purl.uniprot.org/uniprot/#_B4DYR6-mappedCitation-28294974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28294974 |
| http://purl.uniprot.org/uniprot/#_B4DPZ9-mappedCitation-28294974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28294974 |