http://purl.uniprot.org/citations/28295005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/28295005 | http://www.w3.org/2000/01/rdf-schema#comment | "Aimthe evaluation of localization claudin-1, -3 and -4 types of cancer and colon polyps.Material and methodsThe study included 32 colon adenocarcinoma and 86 polyps. Antibody claudin-1; -3 and -4 were used as immunohistochemical markers in this study.Results84/118, 64/118, 52/118 reaction with claudin-1, claudin-3 and claudin-4 in cancer and colon polyps had a membrane localization, respectively. In 33 (27.9%) cases was found paradoxical reaction claudin-1; in 50 (42.4%) - a paradoxical reaction claudin-3 in 66 (55.9%) - a paradoxical reaction claudin-4. Among the paradoxical claudin reaction nuclear localization of marker was observed relatively rarely: claudin-3 in 2.5% cases of colon cancer; claudin-4 in 8.5% of colon polyps.ConclusionMislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided."xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.org/dc/terms/identifier | "doi:10.17116/patol201779128-35"xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/author | "Danilova N.V."xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/author | "Kharlova O.A."xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/author | "Mal'kov P.G."xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/author | "Oleinikova N.A."xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/name | "Arkh Patol"xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/pages | "28-35"xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/title | "[The expression of claudins in colonic neoplasms]."xsd:string |
http://purl.uniprot.org/citations/28295005 | http://purl.uniprot.org/core/volume | "79"xsd:string |
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