| http://purl.uniprot.org/citations/28295031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28295031 | http://www.w3.org/2000/01/rdf-schema#comment | "As a consequence of its difference in copy number between males and females, the X chromosome is subject to unique evolutionary forces and gene regulatory mechanisms. Previous studies of Drosophila melanogaster have shown that the expression of X-linked, testis-specific reporter genes is suppressed in the male germline. However, it is not known whether this phenomenon is restricted to testis-expressed genes or if it is a more general property of genes with tissue-specific expression, which are also underrepresented on the X chromosome. To test this, we compared the expression of three tissue-specific reporter genes (ovary, accessory gland and Malpighian tubule) inserted at various autosomal and X-chromosomal locations. In contrast to testis-specific reporter genes, we found no reduction of X-linked expression in any of the other tissues. In accessory gland and Malpighian tubule, we detected higher expression of the X-linked reporter genes, which suggests that they are at least partially dosage compensated. We found no difference in the tissue-specificity of X-linked and autosomal reporter genes. These findings indicate that, in general, the X chromosome is not a detrimental environment for tissue-specific gene expression and that the suppression of X-linked expression is limited to the male germline."xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.org/dc/terms/identifier | "doi:10.1038/hdy.2017.12"xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/author | "Parsch J."xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/author | "Huylmans A.K."xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/author | "Argyridou E."xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/author | "Koniger A."xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/name | "Heredity (Edinb)"xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/pages | "27-34"xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/title | "X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/28295031 | http://purl.uniprot.org/core/volume | "119"xsd:string |
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| http://purl.uniprot.org/citations/28295031 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28295031 |
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| http://purl.uniprot.org/uniprot/#_M9NG31-mappedCitation-28295031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28295031 |
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| http://purl.uniprot.org/uniprot/#_M9NEY9-mappedCitation-28295031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28295031 |
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