| http://purl.uniprot.org/citations/28298526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28298526 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of proinflammatory macrophages is associated with the inflammatory state of rheumatoid arthritis. Their polarization and activation are controlled by transcription factors such as NF-κB and the AP-1 transcription factor member c-Fos. Surprisingly, little is known about the role of the AP-1 transcription factor c-Jun in macrophage activation. In this study, we show that mRNA and protein levels of c-Jun are increased in macrophages following pro- or anti-inflammatory stimulations. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment cluster analyses of microarray data using wild-type and c-Jun-deleted macrophages highlight the central function of c-Jun in macrophages, in particular for immune responses, IL production, and hypoxia pathways. Mice deficient for c-Jun in macrophages show an amelioration of inflammation and bone destruction in the serum-induced arthritis model. In vivo and in vitro gene profiling, together with chromatin immunoprecipitation analysis of macrophages, revealed direct activation of the proinflammatory factor cyclooxygenase-2 and indirect inhibition of the anti-inflammatory factor arginase-1 by c-Jun. Thus, c-Jun regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 and arginase-1 levels."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1601330"xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Paul S."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Jordan J."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Reid S."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Sonnewald S."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Vera J."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Bozec A."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Schett G."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Bauerle T."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Hannemann N."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/author | "Baenkler H.W."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/pages | "3605-3614"xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/title | "The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages."xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/28298526 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28298526 |
| http://purl.uniprot.org/citations/28298526 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28298526 |
| http://purl.uniprot.org/uniprot/#_A0A087WPT2-mappedCitation-28298526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28298526 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-28298526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28298526 |
| http://purl.uniprot.org/uniprot/#_Q52L79-mappedCitation-28298526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28298526 |
| http://purl.uniprot.org/uniprot/#_Q3V255-mappedCitation-28298526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28298526 |
| http://purl.uniprot.org/uniprot/#_Q3UMR6-mappedCitation-28298526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28298526 |