| http://purl.uniprot.org/citations/28300532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28300532 | http://www.w3.org/2000/01/rdf-schema#comment | "ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor RF2, which normally binds stop codons to catalyze peptide release. We report two 3.2 Å resolution cryo-EM structures - determined from a single sample - of the 70S ribosome with ArfA•RF2 in the A site. In both states, the ArfA C-terminus occupies the mRNA tunnel downstream of the A site. One state contains a compact inactive RF2 conformation. Ordering of the ArfA N-terminus in the second state rearranges RF2 into an extended conformation that docks the catalytic GGQ motif into the peptidyl-transferase center. Our work thus reveals the structural dynamics of ribosome rescue. The structures demonstrate how ArfA 'senses' the vacant mRNA tunnel and activates RF2 to mediate peptide release without a stop codon, allowing stalled ribosomes to be recycled."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.23687"xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Sousa D."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Grigorieff N."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Diaz-Avalos R."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Grant T."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Demo G."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Korostelev A.A."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Madireddy R."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/author | "Svidritskiy E."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/pages | "e23687"xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/title | "Mechanism of ribosome rescue by ArfA and RF2."xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28300532 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28300532 |
| http://purl.uniprot.org/citations/28300532 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28300532 |
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| http://purl.uniprot.org/uniprot/#_P0AG59-mappedCitation-28300532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28300532 |