| http://purl.uniprot.org/citations/28320969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28320969 | http://www.w3.org/2000/01/rdf-schema#comment | "Vasodilator-stimulated phosphoprotein (VASP) and Ena-VASP-like (EVL) are cytoskeletal effector proteins implicated in regulating cell morphology, adhesion, and migration in various cell types. However, the role of these proteins in T-cell motility, adhesion, and in vivo trafficking remains poorly understood. This study identifies a specific role for EVL and VASP in T-cell diapedesis and trafficking. We demonstrate that EVL and VASP are selectively required for activated T-cell trafficking but are not required for normal T-cell development or for naïve T-cell trafficking to lymph nodes and spleen. Using a model of multiple sclerosis, we show an impairment in trafficking of EVL/VASP-deficient activated T cells to the inflamed central nervous system of mice with experimental autoimmune encephalomyelitis. Additionally, we found a defect in trafficking of EVL/VASP double-knockout (dKO) T cells to the inflamed skin and secondary lymphoid organs. Deletion of EVL and VASP resulted in the impairment in α4 integrin (CD49d) expression and function. Unexpectedly, EVL/VASP dKO T cells did not exhibit alterations in shear-resistant adhesion to, or in crawling on, primary endothelial cells under physiologic shear forces. Instead, deletion of EVL and VASP impaired T-cell diapedesis. Furthermore, T-cell diapedesis became equivalent between control and EVL/VASP dKO T cells upon α4 integrin blockade. Overall, EVL and VASP selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a α4 integrin-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1701886114"xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/author | "Jacobelli J."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/author | "Fisher M.H."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/author | "Friedman R.S."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/author | "Estin M.L."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/author | "Thompson S.B."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/author | "Traxinger B."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/pages | "E2901-E2910"xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/title | "Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration."xsd:string |
| http://purl.uniprot.org/citations/28320969 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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