| http://purl.uniprot.org/citations/28323620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28323620 | http://www.w3.org/2000/01/rdf-schema#comment | "We wish to identify determinants of endothelial lineage. Murine embryonic stem cells (mESC) were fused with human endothelial cells in stable, non-dividing, heterokaryons. Using RNA-seq, it is possible to discriminate between human and mouse transcripts in these chimeric heterokaryons. We observed a temporal pattern of gene expression in the ESCs of the heterokaryons that recapitulated ontogeny, with early mesodermal factors being expressed before mature endothelial genes. A set of transcriptional factors not known to be involved in endothelial development was upregulated, one of which was POU class 3 homeobox 2 (Pou3f2). We confirmed its importance in differentiation to endothelial lineage via loss- and gain-of-function (LOF and GOF). Its role in vascular development was validated in zebrafish embryos using morpholino oligonucleotides. These studies provide a systematic and mechanistic approach for identifying key regulators in directed differentiation of pluripotent stem cells to somatic cell lineages."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.23588"xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Meng S."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Tian X."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Wong W.T."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Blau H.M."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Chen J.K."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Burns D.M."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Matrone G."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Au K.F."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Yamazoe S."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Cooke J.P."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Sieveking D."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/author | "Tomoiaga S.A."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/pages | "e23588"xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/title | "Discovery of novel determinants of endothelial lineage using chimeric heterokaryons."xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28323620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28323620 |
| http://purl.uniprot.org/citations/28323620 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28323620 |
| http://purl.uniprot.org/uniprot/P79746#attribution-B6C25EABBE68678BDB70F6682B301C67 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28323620 |
| http://purl.uniprot.org/uniprot/#_P79746-mappedCitation-28323620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28323620 |