| http://purl.uniprot.org/citations/28334814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28334814 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetic architecture of adolescent idiopathic scoliosis (AIS) remains poorly understood. Here we present the result of a 4-stage genome-wide association study composed of 5,953 AIS patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 (Pcombined = 1.19 × 10-13, OR = 1.21, 95% CI = 1.10-1.32), rs7633294 at 3p14.1 near MAGI1 (Pcombined = 1.85 × 10-12, OR = 1.20, 95% CI = 1.09-1.32), and rs9810566 at 3q26.2 near TNIK (Pcombined = 1.14 × 10-11, OR = 1.19, 95% CI = 1.08-1.32). We also confirmed a recently reported region associated with AIS at 20p11.22 (Pcombined = 1.61 × 10-15, OR = 1.22, 95% CI = 1.12-1.34). Furthermore, we observed significantly asymmetric expression of Wnt/beta-catenin pathway in the bilateral paraspinal muscle of AIS patients, including beta-catenin, TNIK, and LBX1. This is the first study that unveils the potential role of Wnt/beta-catenin pathway in the development of AIS, and our findings may shed new light on the etiopathogenesis of AIS."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddx045"xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Feng Z."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Qin X."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Qiao J."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Shi B."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Mao S."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Chun-Yiu Cheng J."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/author | "Leung-Sang Tang N."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/pages | "1577-1583"xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/title | "Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis."xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/28334814 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28334814 |