| http://purl.uniprot.org/citations/28336944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28336944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28336944 | http://www.w3.org/2000/01/rdf-schema#comment | "Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. KSHV establishes a life-long infection in its host and alternates between a latent and lytic infection state. During lytic infection, lytic-related genes are expressed in a temporal manner and categorized as immediate early, early, and late gene transcripts. ORF34 is an early-late gene that interacts with several viral transcription-associated factors, however its physiological importance remains poorly understood. Here, we investigated the role of ORF34 during KSHV infection by generating ORF34-deficient KSHV, using a bacterial artificial chromosome system. Our results reveal that ORF34-deficient KSHV exhibited significantly attenuated late gene expression and viral production but did not affect viral DNA replication. ORF34 interacted with transcription factors ORF18, ORF24, ORF31, and ORF66, and a novel ORF34-interaction partner, ORF23. The C-terminal region of ORF34 was important for interaction with ORF24 and viral production. Our data support a model, in which ORF34 serves as a hub for recruiting a viral transcription complex to ORF24 to promote late viral gene expression."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-00401-7"xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-00401-7"xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Nishimura M."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Nishimura M."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Yamanaka T."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Yamanaka T."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Fujimuro M."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Fujimuro M."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Yagi S."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/author | "Yagi S."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/pages | "329"xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/pages | "329"xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/title | "Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/title | "Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production."xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28336944 | http://purl.uniprot.org/core/volume | "7"xsd:string |