| http://purl.uniprot.org/citations/28340350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28340350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28340350 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ligand for the inhibitory and activating NKR-P1 (NK1.1) receptors. This murine cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging the inhibitory NKR-P1B receptor. However, m12 also interacts with the activating NKR-P1A/C receptors to counterbalance m12 decoy function. Structural analyses reveal that m12 sequesters a large NKR-P1 surface area via a "polar claw" mechanism. Polymorphisms in, and ablation of, the viral m12 protein and host NKR-P1B/C alleles impact NK cell responses in vivo. Thus, we identify the long-sought foreign ligand for this key immunoregulatory NKR family and reveal how it controls the evolutionary balance of immune recognition during host-pathogen interplay."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2017.03.002"xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2017.03.002"xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Popovic B."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Popovic B."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Jonjic S."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Jonjic S."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Berry R."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Berry R."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Allan D.S."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Allan D.S.J."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Makrigiannis A.P."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Makrigiannis A.P."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Mesci A."xsd:string |
| http://purl.uniprot.org/citations/28340350 | http://purl.uniprot.org/core/author | "Mesci A."xsd:string |