| http://purl.uniprot.org/citations/28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28340506 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcome for patients, although the mechanism through which it exerts this effect remained unexplained. Investigating this, here we found that ectopic over-expression of NmU in HER2-positive breast cancer cells induced aberrant metabolism, with increased glycolysis, likely due to enhanced pyruvate dehydrogenase kinase activity. Similar results were observed in HER2-targeted drug-resistant cell variants, which we had previously shown to display increased levels of NmU. Overexpression of NmU also resulted in upregulation of epithelial-mesenchymal transition markers and increased IL-6 secretion which, together with aberrant metabolism, have all been associated with the cancer stem cell (CSC) phenotype. Flow cytometry experiments confirmed that NmU-overexpressing and HER2-targeted drug-resistant cells showed an increased proportion of cells with CSC phenotype (CD44+ /CD24- ). Taken together, our results report a new mechanism of action for NmU in HER2-overexpressing breast cancer that enhances resistance to HER2-targeted drugs through conferring CSC characteristics and expansion of the CSC phenotype."xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.30705"xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/author | "Martinez V.G."xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/author | "Crown J."xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/author | "O'Driscoll L."xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/author | "Porter R.K."xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/pages | "2771-2784"xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/title | "Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer."xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://purl.uniprot.org/core/volume | "140"xsd:string |
| http://purl.uniprot.org/citations/28340506 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28340506 |
| http://purl.uniprot.org/citations/28340506 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28340506 |
| http://purl.uniprot.org/uniprot/#_E9PDJ7-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J202-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_A0A8A0Y2Q6-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_A0A250SH36-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_A0A0R9RWK2-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_E2I6F8-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_B4DTR1-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_D6RBC9-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_B4DLA2-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_J3QLU9-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |
| http://purl.uniprot.org/uniprot/#_F5H1T4-mappedCitation-28340506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28340506 |