| http://purl.uniprot.org/citations/2834197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2834197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2834197 | http://www.w3.org/2000/01/rdf-schema#comment | "The most common translocation in human lymphoma, the t(14;18)(q32;q21), generates heterogeneous 4.2-7.2 kb Bcl-2-immunoglobulin (Ig) chimeric mRNAs resulting from alternative Bcl-2 5' exons and varied Ig 3' untranslated regions (UT). The normal human Bcl-2 gene has a three exon structure with an untranslated first exon, a facultative 220 bp intron I, but an enormous 370 kb intron II. S1 protection and primer extension analysis defined initiation sites in exon II associated with classic promoter elements and a decanucleotide (ATG-CAAAGCA) homologous with Ig variable region enhancers. Multiple initiation sites were also found in a GC-rich region with Sp1 binding motifs in exon I. Most t(14;18) breakpoints cluster within the 3' UT of Bcl-2 implicating that event in gene deregulation. The Bcl-2 gene introduced into the Ig constant (C gamma) locus of SU-DHL-6 displayed somatic mutation. While Bcl-2--Ig mRNAs demonstrated an unaltered 2.5 h half-life, the Bcl-2--Ig gene revealed an inappropriately high rate of transcription for a mature B-cell. This indicates the translocated Bcl-2 allele has escaped normal control mechanisms."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1988.tb02791.x"xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1988.tb02791.x"xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Bennett S."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Bennett S."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Jaeger U."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Jaeger U."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Goldman P."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Goldman P."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Graninger W."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Graninger W."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Hockett R.D."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Hockett R.D."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Seto M."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/author | "Seto M."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/pages | "123-131"xsd:string |
| http://purl.uniprot.org/citations/2834197 | http://purl.uniprot.org/core/pages | "123-131"xsd:string |