| http://purl.uniprot.org/citations/28344041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28344041 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have shown that kisspeptin neurons are important mediators of prolactin's effects on reproduction. However, the cellular mechanisms recruited by prolactin to affect kisspeptin neurons remain unknown. Using whole-cell patch-clamp recordings of brain slices from kisspeptin reporter mice, we observed that 20% of kisspeptin neurons in the anteroventral periventricular nucleus was indirectly depolarized by prolactin via an unknown population of prolactin responsive neurons. This effect required the phosphatidylinositol 3-kinase signaling pathway. No effects on the activity of arcuate kisspeptin neurons were observed, despite a high percentage (70%) of arcuate neurons expressing prolactin-induced STAT5 phosphorylation. To determine whether STAT5 expression in kisspeptin cells regulates reproduction, mice carrying Stat5a/b inactivation specifically in kisspeptin cells were generated. These mutants exhibited an early onset of estrous cyclicity, indicating that STAT5 transcription factors exert an inhibitory effect on the timing of puberty."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2017.03.024"xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "Frazao R."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "Franci C.R."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "Donato J. Jr."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "Furigo I.C."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "Zampieri T.T."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "Silveira M.A."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "Bohlen T.M."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/author | "de Paula D.G."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/pages | "55-65"xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/title | "STAT5 signaling in kisspeptin cells regulates the timing of puberty."xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://purl.uniprot.org/core/volume | "448"xsd:string |
| http://purl.uniprot.org/citations/28344041 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28344041 |
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