| http://purl.uniprot.org/citations/28344080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28344080 | http://www.w3.org/2000/01/rdf-schema#comment | "Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing ribosome footprinting from fly heads, we demonstrate that a group of circRNAs is associated with translating ribosomes. Many of these ribo-circRNAs use the start codon of the hosting mRNA, are bound by membrane-associated ribosomes, and have evolutionarily conserved termination codons. In addition, we found that a circRNA generated from the muscleblind locus encodes a protein, which we detected in fly head extracts by mass spectrometry. Next, by performing in vivo and in vitro translation assays, we show that UTRs of ribo-circRNAs (cUTRs) allow cap-independent translation. Moreover, we found that starvation and FOXO likely regulate the translation of a circMbl isoform. Altogether, our study provides strong evidence for translation of circRNAs, revealing the existence of an unexplored layer of gene activity."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.02.021"xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Samson M."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Landthaler M."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Wyler E."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Dittmar G."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Kadener S."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Chekulaeva M."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Jens M."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Rajewsky N."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Perez-Hernandez D."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Ashwal-Fluss R."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Bartok O."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Hanan M."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Stottmeister C."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Pamudurti N.R."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Ramberger E."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Ruhe L."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/author | "Shenzis S."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/pages | "9-21.e7"xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/title | "Translation of CircRNAs."xsd:string |
| http://purl.uniprot.org/citations/28344080 | http://purl.uniprot.org/core/volume | "66"xsd:string |