| http://purl.uniprot.org/citations/28345588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28345588 | http://www.w3.org/2000/01/rdf-schema#comment | "Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen-anagen transition (TAT) around the wound and de novo HF regeneration, mostly through TNF signalling. Both TNF knockout and overexpression attenuate HF neogenesis in wounds, suggesting dose-dependent induction of HF neogenesis by TNF, which is consistent with TNF-induced AKT signalling in epidermal stem cells in vitro. TNF-induced β-catenin accumulation is dependent on AKT but not Wnt signalling. Inhibition of PI3K/AKT blocks depilation-induced HF TAT. Notably, Pten loss in Lgr5+ HF stem cells results in HF TAT independent of injury and promotes HF neogenesis after wounding. Thus, our results suggest that macrophage-TNF-induced AKT/β-catenin signalling in Lgr5+ HF stem cells has a crucial role in promoting HF cycling and neogenesis after wounding."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14091"xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Cai T."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Ge J."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Jia H."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Liu J.'"xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Lin M."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Fan Z."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Tian R."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Wang X.'"xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Qin Z."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Kong D."xsd:string |
| http://purl.uniprot.org/citations/28345588 | http://purl.uniprot.org/core/author | "Nedospasov S.A."xsd:string |