| http://purl.uniprot.org/citations/28347247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28347247 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA-binding motif 5 is a putative tumor suppressor gene that modulates cell cycle arrest and apoptosis. We recently demonstrated that RNA-binding motif 5 inhibits cell growth through the p53 pathway. This study evaluated the clinical significance of RNA-binding motif 5 expression in gastric cancer and the effects of altered RNA-binding motif 5 expression on cancer biology in gastric cancer cells. RNA-binding motif 5 protein expression was evaluated by immunohistochemistry using the surgical specimens of 106 patients with gastric cancer. We analyzed the relationships of RNA-binding motif 5 expression with clinicopathological parameters and patient prognosis. We further explored the effects of RNA-binding motif 5 downregulation with short hairpin RNA on cell growth and p53 signaling in MKN45 gastric cancer cells. Immunohistochemistry revealed that RNA-binding motif 5 expression was decreased in 29 of 106 (27.4%) gastric cancer specimens. Decreased RNA-binding motif 5 expression was correlated with histological differentiation, depth of tumor infiltration, nodal metastasis, tumor-node-metastasis stage, and prognosis. RNA-binding motif 5 silencing enhanced gastric cancer cell proliferation and decreased p53 transcriptional activity in reporter gene assays. Conversely, restoration of RNA-binding motif 5 expression suppressed cell growth and recovered p53 transactivation in RNA-binding motif 5-silenced cells. Furthermore, RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.org/dc/terms/identifier | "doi:10.1177/1010428317694547"xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Ishida J."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Muranaka T."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Sakamoto N."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Shimizu Y."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Kawakami H."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Komatsu Y."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Asaka M."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/author | "Suda G."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/pages | "1010428317694547"xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/title | "Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/28347247 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28347247 |
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| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-28347247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28347247 |