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http://purl.uniprot.org/citations/28348105http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28348105http://www.w3.org/2000/01/rdf-schema#comment"α-Catenin is an F-actin-binding protein widely recognized for its role in cell-cell adhesion. However, a growing body of literature indicates that α-catenin is also a nuclear protein. In this study, we show that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenin-dependent manner and requires nuclear actin polymerization. These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the α-catenin-β-catenin complex in the nucleus."xsd:string
http://purl.uniprot.org/citations/28348105http://purl.org/dc/terms/identifier"doi:10.1242/jcs.199893"xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/author"Gottardi C.J."xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/author"de Lanerolle P."xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/author"Yemelyanov A."xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/author"Serebryannyy L.A."xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/name"J Cell Sci"xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/pages"1717-1729"xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/title"Nuclear alpha-catenin mediates the DNA damage response via beta-catenin and nuclear actin."xsd:string
http://purl.uniprot.org/citations/28348105http://purl.uniprot.org/core/volume"130"xsd:string
http://purl.uniprot.org/citations/28348105http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28348105
http://purl.uniprot.org/citations/28348105http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28348105
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http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-28348105http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28348105
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http://purl.uniprot.org/uniprot/#_B4DKT9-mappedCitation-28348105http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28348105
http://purl.uniprot.org/uniprot/#_B4DL06-mappedCitation-28348105http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28348105
http://purl.uniprot.org/uniprot/#_B4DU00-mappedCitation-28348105http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28348105
http://purl.uniprot.org/uniprot/#_B4E2G8-mappedCitation-28348105http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28348105
http://purl.uniprot.org/uniprot/#_B5BU28-mappedCitation-28348105http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28348105