| http://purl.uniprot.org/citations/28348409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28348409 | http://www.w3.org/2000/01/rdf-schema#comment | "TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target mutant-p53 cancers are urgently needed. We show that accumulated mutant-p53 protein suppresses the expression of SLC7A11, a component of the cystine/glutamate antiporter, system xC-, through binding to the master antioxidant transcription factor NRF2. This diminishes glutathione synthesis, rendering mutant-p53 tumours susceptible to oxidative damage. System xC- inhibitors specifically exploit this vulnerability to preferentially kill cancer cells with stabilized mutant-p53 protein. Moreover, we demonstrate that SLC7A11 expression is a novel and robust predictive biomarker for APR-246, a first-in-class mutant-p53 reactivator that also binds and depletes glutathione in tumours, triggering lipid peroxidative cell death. Importantly, system xC- antagonism strongly synergizes with APR-246 to induce apoptosis in mutant-p53 tumours. We propose a new paradigm for targeting cancers that accumulate mutant-p53 protein by inhibiting the SLC7A11-glutathione axis."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14844"xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Read M."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "House C.M."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Liu D.S."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Phillips W.A."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Haupt S."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Abrahmsen L."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Haupt Y."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Wiman K.G."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Montgomery K.G."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Azar W.J."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Clemons N.J."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Cullinane C."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Pearson H.B."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Duong C.P."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Fisher O.M."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/author | "Guerra G.R."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/pages | "14844"xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/title | "Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation."xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28348409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28348409 |