| http://purl.uniprot.org/citations/28351301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28351301 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of apoptosis-stimulating protein 2 of p53 (ASPP2) induces apoptotic cell death in hepatoma cells (e.g. HepG2 cells) by enhancing the transactivation activity of p53, but long-term ASPP2 overexpression fails to induce more apoptosis since activation of the epidermal growth factor/epidermal growth factor receptor/SOS1 pathway impairs the pro-apoptotic role of ASPP2. In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin expression in a p53-dependent manner. Although amphiregulin initially contributes to ASPP2-induced apoptosis, it eventually impairs the pro-apoptotic function of ASPP2 by activating the epidermal growth factor/epidermal growth factor receptor/SOS1 pathway, leading to apoptosis resistance. Moreover, blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis. Thus, our data elucidate an apoptosis-evasion mechanism in hepatocellular carcinoma and have potential implications for hepatocellular carcinoma therapy."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.org/dc/terms/identifier | "doi:10.1177/1010428317695026"xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Lin D."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Liu K."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Ouyang Y."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Pang L."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/author | "Zang Y."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/pages | "1010428317695026"xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/title | "Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells."xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/28351301 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28351301 |
| http://purl.uniprot.org/citations/28351301 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28351301 |
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