| http://purl.uniprot.org/citations/28360037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28360037 | http://www.w3.org/2000/01/rdf-schema#comment | "Changes in mitochondrial DNA (mtDNA) integrity have been reported in many cancers; however, the contribution of mtDNA integrity to tumorigenesis is not well understood. We used a transgenic mouse model that is haploinsufficient for the apurinic/apyrimidinic endonuclease 1 (Apex1+/-) gene, which encodes the base excision repair (BER) enzyme APE1, to determine its role in protecting mtDNA from the effects of azoxymethane (AOM), a carcinogen used to induce colorectal cancer. Repair kinetics of AOM-induced mtDNA damage was evaluated using qPCR after a single AOM dose and a significant induction in mtDNA lesions in colonic crypts from both wild-type (WT) and Apex1+/-animals were observed. However, Apex1+/- mice had slower repair kinetics in addition to decreased mtDNA abundance. Tumors were also induced using multiple AOM doses, and both WT and Apex1+/-animals exhibited significant loss in mtDNA abundance. Surprisingly, no major differences in mtDNA lesions were observed in tumors from WT and Apex1+/- animals, whereas a significant increase in nuclear DNA lesions was detected in tumors from Apex1+/- mice. Finally, tumors from Apex1+/- mice displayed an increased proliferative index and histologic abnormalities. Taken together, these results demonstrate that APE1 is important for preventing changes in mtDNA integrity during AOM-induced colorectal cancer.Implications: AOM, a colorectal cancer carcinogen, generates damage to the mitochondrial genome, and the BER enzyme APE1 is required to maintain its integrity. Mol Cancer Res; 15(7); 831-41. ©2017 AACR."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-16-0218"xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Torres-Ramos C.A."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Torres C."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Climent C."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Martinez-Ferrer M."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Ayala-Pena S."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Rodriguez-Munoz A."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Velez R."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Ballista-Hernandez J."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/author | "Sanchez-Vazquez M.M."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/name | "Mol Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/pages | "831-841"xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/title | "Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer."xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/28360037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28360037 |
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| http://purl.uniprot.org/uniprot/#_P28352-mappedCitation-28360037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28360037 |
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| http://purl.uniprot.org/uniprot/P28352 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28360037 |