| http://purl.uniprot.org/citations/28361903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28361903 | http://www.w3.org/2000/01/rdf-schema#comment | "Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweeteners in consumer foods and beverages. TRPM5 is a Ca2+-activated cation channel expressed in type II taste receptor cells and pancreatic β-cells. Here we show that stevioside, rebaudioside A and their aglycon steviol potentiate the activity of TRPM5. We find that SGs potentiate perception of bitter, sweet and umami taste, and enhance glucose-induced insulin secretion in a Trpm5-dependent manner. Daily consumption of stevioside prevents development of high-fat-diet-induced diabetic hyperglycaemia in wild-type mice, but not in Trpm5-/- mice. These results elucidate a molecular mechanism of action of SGs and identify TRPM5 as a potential target to prevent and treat type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14733"xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Tytgat J."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Schuit F."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Cuypers E."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Pinto S."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Mathieu C."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Voets T."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Talavera K."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Lemaire K."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Rorsman P."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Gilon P."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Segal A."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Vennekens R."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Vermeiren L."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Gysemans C."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Laureys J."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Antoine N."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Kerselaers S."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Sones W."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Philippaert K."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Mesuere M."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/author | "Pironet A."xsd:string |
| http://purl.uniprot.org/citations/28361903 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |