| http://purl.uniprot.org/citations/28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28362432 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin is a key component of the regulatory network that maintains gene expression in eukaryotes, yet the molecular mechanism(s) by which non-degradative ubiquitination modulates transcriptional activator (TA) function is unknown. Here endogenous p53, a stress-activated transcription factor required to maintain health, is stably monoubiquitinated, following pathway activation by IR or Nutlin-3 and localized to the nucleus where it becomes tightly associated with chromatin. Comparative structure-function analysis and in silico modelling demonstrate a direct role for DNA-binding domain (DBD) monoubiquitination in TA activation. When attached to the DBD of either p53, or a second TA IRF-1, ubiquitin is orientated towards, and makes contact with, the DNA. The contact is made between a predominantly cationic surface on ubiquitin and the anionic DNA. Our data demonstrate an unexpected role for ubiquitin in the mechanism of TA-activity enhancement and provides insight into a new level of transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2017.42"xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/author | "Hupp T.R."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/author | "Verma C."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/author | "Gilbert N."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/author | "Ball K.L."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/author | "Landre V."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/author | "Mir M.G."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/author | "Revi B."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/pages | "903-916"xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/title | "Regulation of transcriptional activators by DNA-binding domain ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/28362432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28362432 |
| http://purl.uniprot.org/citations/28362432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-28362432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28362432 |