| http://purl.uniprot.org/citations/28368470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28368470 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify circulating GC concentrations. Therefore, 11β-HSD1 could modulate the impact of GCs on BAT function. This study investigated how 11β-HSD1 regulates the molecular architecture of BAT in the context of GC excess and aging. Circulating GC excess was induced in 11β-HSD1 knockout (KO) and wild-type mice by supplementing drinking water with 100 μg/mL corticosterone, and the effects on molecular markers of BAT function and mitochondrial activity were assessed. Brown adipocyte primary cultures were used to examine cell autonomous consequences of 11β-HSD1 deficiency. Molecular markers of BAT function were also examined in aged 11β-HSD1 KO mice to model lifetime GC exposure. BAT 11β-HSD1 expression and activity were elevated in response to GC excess and with aging. 11β-HSD1 KO BAT resisted the suppression of uncoupling protein 1 (UCP1) and mitochondrial respiratory chain subunit proteins normally imposed by GC excess. Furthermore, brown adipocytes from 11β-HSD1 KO mice had elevated basal mitochondrial function and were able to resist GC-mediated repression of activity. BAT from aged 11β-HSD1 KO mice showed elevated UCP1 protein and mitochondrial content, and a favorable profile of BAT function. These data reveal a novel mechanism in which increased 11β-HSD1 expression, in the context of GC excess and aging, impairs the molecular and metabolic function of BAT."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2016-1722"xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Fletcher R.S."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Stewart P.M."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Philp A."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Lavery G.G."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Tomlinson J.W."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Morgan S.A."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Doig C.L."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "McCabe E.L."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/author | "Larner D.P."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/pages | "1964-1976"xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/title | "11beta-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice."xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://purl.uniprot.org/core/volume | "158"xsd:string |
| http://purl.uniprot.org/citations/28368470 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28368470 |
| http://purl.uniprot.org/citations/28368470 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28368470 |
| http://purl.uniprot.org/uniprot/#_F2Z3U6-mappedCitation-28368470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28368470 |
| http://purl.uniprot.org/uniprot/#_F6TSI8-mappedCitation-28368470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28368470 |
| http://purl.uniprot.org/uniprot/#_P50172-mappedCitation-28368470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28368470 |
| http://purl.uniprot.org/uniprot/#_Q4JHD9-mappedCitation-28368470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28368470 |
| http://purl.uniprot.org/uniprot/#_Q3TJI8-mappedCitation-28368470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28368470 |
| http://purl.uniprot.org/uniprot/F6TSI8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28368470 |