| http://purl.uniprot.org/citations/28369605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28369605 | http://www.w3.org/2000/01/rdf-schema#comment | "G-quadruplex or G4 DNA is a non-B secondary DNA structure consisting of a stacked array of guanine-quartets that can disrupt critical cellular functions such as replication and transcription. When sequences that can adopt Non-B structures including G4 DNA are located within actively transcribed genes, the reshaping of DNA topology necessary for transcription process stimulates secondary structure-formation thereby amplifying the potential for genome instability. Using a reporter assay designed to study G4-induced recombination in the context of an actively transcribed locus in Saccharomyces cerevisiae, we tested whether co-transcriptional activator Sub1, recently identified as a G4-binding factor, contributes to genome maintenance at G4-forming sequences. Our data indicate that, upon Sub1-disruption, genome instability linked to co-transcriptionally formed G4 DNA in Top1-deficient cells is significantly augmented and that its highly conserved DNA binding domain or the human homolog PC4 is sufficient to suppress G4-associated genome instability. We also show that Sub1 interacts specifically with co-transcriptionally formed G4 DNA in vivo and that yeast cells become highly sensitivity to G4-stabilizing chemical ligands by the loss of Sub1. Finally, we demonstrate the physical and genetic interaction of Sub1 with the G4-resolving helicase Pif1, suggesting a possible mechanism by which Sub1 suppresses instability at G4 DNA."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkx201"xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Kim N."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Singh S."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Raney K.D."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Ira G."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Chib S."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Lopez C.R."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Griffin W.C."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/author | "Hambarde S."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/pages | "5850-5862"xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/title | "Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA."xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/28369605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28369605 |
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