DESCRIBE <http://purl.uniprot.org/citations/28370690>

Subject	Predicate	Object
http://purl.uniprot.org/citations/28370690	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28370690	http://www.w3.org/2000/01/rdf-schema#comment	" Objectives Osteosarcoma is the most commonly diagnosed primary malignancy of bone and its overall survival rate is still very low. The molecular mechanisms underlying the progression of osteosarcoma have not been clearly illuminated. Heat shock transcription factor 1 (HSF1) is a key regulator of the heat shock response and also plays important roles in many cancers, but its function in osteosarcoma remains unexplored. Materials and methods In this study, the proliferation of osteosarcoma cells was determined by Cell Counting Kit-8 assays and colony formation assays. Transwell assays were used to demonstrate the migration and invasion abilities of osteosarcoma cells. A tumour formation assay in a nude mouse model was performed to assess the effect of HSF1 on osteosarcoma cell growth in vivo. The protein levels of HSF1 were analysed with immunohistochemical staining in samples from osteosarcoma patients. Results We demonstrated that knockdown of HSF1 reduced the proliferation, migration and invasion of osteosarcoma cells, while overexpression of HSF1 promoted the proliferation, migration and invasion of osteosarcoma cells. Furthermore, HSF1 promoted the proliferation of osteosarcoma cells in vivo. In addition, high levels of HSF1 were associated with a poor prognosis in osteosarcoma. Conclusions These data highlight an important role of HSF1 in proliferation, migration and invasion of osteosarcoma cells. Moreover, the expression of HSF1 was associated with prognosis in osteosarcoma."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.org/dc/terms/identifier	"doi:10.1111/cpr.12346"xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/author	"Li Y."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/author	"Hu J."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/author	"Zhou Z."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/author	"Wang Z."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/author	"Wang X."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/author	"Xiao J."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/author	"Jia Q."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/date	"2017"xsd:gYear
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/name	"Cell Prolif"xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/title	"Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells."xsd:string
http://purl.uniprot.org/citations/28370690	http://purl.uniprot.org/core/volume	"50"xsd:string
http://purl.uniprot.org/citations/28370690	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/28370690
http://purl.uniprot.org/citations/28370690	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/28370690
http://purl.uniprot.org/uniprot/#_B3KNQ9-mappedCitation-28370690	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/#_B4DTG4-mappedCitation-28370690	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/#_B3KWP0-mappedCitation-28370690	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/#_Q00613-mappedCitation-28370690	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/#_Q53HT3-mappedCitation-28370690	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/#_Q9HAV2-mappedCitation-28370690	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/B3KWP0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/B3KNQ9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28370690
http://purl.uniprot.org/uniprot/Q00613	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28370690