| http://purl.uniprot.org/citations/28373600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28373600 | http://www.w3.org/2000/01/rdf-schema#comment | "Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrades damaged proteins in an ATP-independent manner. Exposure to very low, non-toxic, signaling concentrations of the redox-signaling agent hydrogen peroxide (H2O2) cause adaptive increases in the de novo expression and proteolytic activity/capacity of the 20S proteasome in female D. melanogaster (fruit-flies). Female 20S proteasome induction was accompanied by increased tolerance to a subsequent normally toxic but sub-lethal amount of H2O2, and blocking adaptive increases in proteasome expression also prevented full adaptation. We find, however, that this adaptive response is both sex- and age-dependent. Both increased proteasome expression and activity, and increased oxidative-stress resistance, in female flies, were lost with age. In contrast, male flies exhibited no H2O2 adaptation, irrespective of age. Furthermore, aging caused a generalized increase in basal 20S proteasome expression, but proteolytic activity and adaptation were both compromised. Finally, continual knockdown of Keep1 (the cytosolic inhibitor of Cnc-C) in adults resulted in older flies with greater stress resistance than their age-matched controls, but who still exhibited an age-associated loss of adaptive homeostasis."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.101218"xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/author | "Wong S."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/author | "Davies K.J.A."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/author | "Carney C."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/author | "Tower J."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/author | "Pomatto L.C.D."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/pages | "1153-1185"xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/title | "The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/28373600 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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