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http://purl.uniprot.org/citations/28373767http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28373767http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To evaluate the predictive value of the expression of chromosomal maintenance (CRM)1 and cyclin-dependent kinase (CDK)5 in gastric cancer (GC) patients after gastrectomy.

Methods

A total of 240 GC patients who received standard gastrectomy were enrolled in the study. The expression level of CRM1 and CDK5 was detected by immunohistochemistry. The correlations between CRM1 and CDK5 expression and clinicopathological factors were explored. Univariate and multivariate survival analyses were used to identify prognostic factors for GC. Receiver operating characteristic analysis was used to compare the accuracy of the prediction of clinical outcome by the parameters.

Results

The expression of CRM1 was significantly related to size of primary tumor (P = 0.005), Borrmann type (P = 0.006), degree of differentiation (P = 0.004), depth of invasion (P = 0.008), lymph node metastasis (P = 0.013), TNM stage (P = 0.002) and distant metastasis (P = 0.015). The expression of CDK5 was significantly related to sex (P = 0.048) and Lauren's classification (P = 0.011). Multivariate Cox regression analysis identified that CRM1 and CDK5 co-expression status was an independent prognostic factor for overall survival (OS) of patients with GC. Integration of CRM1 and CDK5 expression could provide additional prognostic value for OS compared with CRM1 or CDK5 expression alone (P = 0.001).

Conclusion

CRM1 and CDK5 co-expression was an independent prognostic factors for GC. Combined CRM1 and CDK5 expression could provide a prognostic model for OS of GC."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.org/dc/terms/identifier"doi:10.3748/wjg.v23.i11.2012"xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Li P."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Lin Y."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Zhang X.L."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Huang C.M."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Chen P.C."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Wang J.B."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Lin J.X."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Xie H.T."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Cao L.L."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Xie J.W."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Sun Y.Q."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/author"Zheng C.H."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/pages"2012-2022"xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/title"Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer."xsd:string
http://purl.uniprot.org/citations/28373767http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/28373767http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28373767
http://purl.uniprot.org/citations/28373767http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28373767
http://purl.uniprot.org/uniprot/#_A0A090N7W4-mappedCitation-28373767http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28373767
http://purl.uniprot.org/uniprot/#_A0A0S2Z355-mappedCitation-28373767http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28373767
http://purl.uniprot.org/uniprot/#_A0A7I2V2Y6-mappedCitation-28373767http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28373767
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